Department of Biochemistry
Welcome!
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Bruce Nicholson, Ph.D.
Professor and Chairman |
In the Department of Biochemistry at
UTHSCSA, we work at the interface
between molecular structures and cell, tissue, and organ function to probe
the essential molecular mechanisms of life and disease. Research in the
labs of our 23 primary faculty, 8 research faculty, and 11 adjunct and
cross-appointed faculty (described under the faculty
link), spans many disciplines, including:
- Cancer Biochemistry
- Cell and Endocrine Signaling
- Computational Biochemistry, Bioinformatics
- Enzymology and Metabolic Regulation
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- Membrane Proteins
- Neurobiological Mechanisms
- Proteomics and Metabolomics
- Structural Biology
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Our faculty have made seminal contributions to many of these areas, and
include a member of the Institute of Medicine, two Fellows of the American
Association for the Advancement of Science, the current president of the
American Mass Spectrometry Society and past presidents of the American
Society for Biochemists and Molecular Biologists and the American Society
of Parasitologists.
The technically complex nature of the molecular and
biophysical studies conducted within the Department demands
sophisticated instrumentation which is housed in several
core facilities,
each of which operates under the guidance of an internationally
recognized expert. These are located in close proximity, facilitating
their multifunctional use and providing a truly unique collaborative
environment within the Department. Traditional strengths in structural
biology within the department have been recently expanded to include a
vigorous program in drug discovery, providing the means for potential
translation of our discoveries to bedside applications. Currently,
facilities located within the department include:
- Macromolecular Interactions - Analytical Ultracentrifugation,
SPR, ITC, SAXS and DLS
- Mass Spectrometry - Proteomics/Metabolomics
- Bioinformatics
- High Throughput Screening for Drug Discovery
- NMR Spectroscopy/Fragment-based Screening
- X-ray Crystallography
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In addition to its research mission, the faculty in Biochemistry,
which includes several Distinguished Teaching Professors, is dedicated
to the training of future scientists at the postdoctoral, graduate, and
professional student (both medical and dental) level. The department
hosts the
Molecular Biophysics
and Biochemistry Track, which trains students to become independent
investigators using biophysical and chemical methods to understand the
molecular mechanisms underlying cellular processes.
As part of the training program, the Department offers an excellent
seminar program, including the popular Horowitz Distinguished Seminar
series where the students choose and invite the speakers. Travel awards
are also available within the Department, and we host an annual retreat
where awards are made to the most outstanding student and postdoctoral
fellow presentations.
On behalf of the faculty, postdoctoral fellows, and students in the
Department, I invite you to get in touch with us -- we will be happy to
visit with you. Our contact information can be found in the People and
the Department Contacts sections on this webpage.
Sincerely,
Bruce J. Nicholson, Ph.D.
Professor and Chair